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Literature summary extracted from

  • Munagala, N.; Nguyen, S.; Lam, W.; Lee, J.; Joly, A.; McMillan, K.; Zhang, W.
    Identification of small molecule ceramide kinase inhibitors using a homogeneous chemiluminescence high throughput assay (2007), Assay Drug Dev. Technol., 5, 65-74.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.1.138 medicine potentially important therapeutic target in oncology and inflammation Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.138 expression in baculovirus-infected SF9 insect cells Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.138 0.031
-
 ATP
-
 Homo sapiens
2.7.1.138 0.107
-
 C12-ceramide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.138 ceramide + ATP Homo sapiens ceramide is a key mediator of cellular apoptosis ceramide 1-phosphate + ADP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.138 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.138 nickel-nitriloacetate resin chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.138 C12-ceramide + ATP
-
 Homo sapiens C12-ceramide 1-phosphate + ADP
-
 ?
2.7.1.138 ceramide + ATP
-
 Homo sapiens ceramide 1-phosphate + ADP
-
 ?
2.7.1.138 ceramide + ATP ceramide is a key mediator of cellular apoptosis Homo sapiens ceramide 1-phosphate + ADP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.138 CERK
-
 Homo sapiens